Cell Adhesion Molecule 3 (CADM3)
BIgR; TSLL1; NECL1; SynCAM3; Necl-1; IGSF4B; Nectin-Like 1; Immunoglobulin Superfamily,Member 4B; Brain immunoglobulin receptor; TSLC1-like protein 1
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins.The predicted 398-amino acid TSLL1 protein has an extracellular domain, a transmembrane domain, and a short cytoplasmic domain. The extracellular domain contains 3 Ig-like, C2-type loops with several potential N-glycosylation sites. NECL1 showed calcium-independent homophilic cell-cell adhesion activity. Furthermore, it showed calcium-independent heterophilic cell-cell adhesion activity with NECL2 (IGSF4), nectin-1 (PVRL1), or nectin-3 (PVRL3), but not with NECL5 (PVR) or nectin-2 (PVRL2). Yeast 2-hybrid analysis indicated that the PDZ domain-binding motif of NECL1 bound to the L27 domain-containing proteins DLG3, PALS2 (MPP6), and CASK, but unlike most other nectins.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Cell Adhesion Molecule 3 (CADM3) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Cell Adhesion Molecule 3 (CADM3) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Cell Adhesion Molecule 3 (CADM3) ELISA Kit Customized Service Offer