Cell Division Cycle Protein 14B (CDC14B)

CDC14B is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.

The predicted 454-amino acid CDC14B protein shares 85% identity with CDC14A. Both proteins contain a protein-tyrosine phosphatase domain. Northern blot analysis revealed that the 6-kb CDC14B mRNA is expressed in all tissues.