Cell Division Cycle Protein 25C (CDC25C)

CDC25C is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis.The product of the human cdc25 homolog shared a conserved C-terminal domain with the yeast and Drosophila cdc25 proteins. Furthermore, the human cdc25 homolog rescued a fission yeast temperature-sensitive mutant form of cdc25, indicating functional as well as structural conservation of cdc25 homologs. The human gene encodes a protein with a predicted molecular mass of 53,000 daltons whose C-terminal domain shares about 37% sequence identity with the fission yeast cdc25 mitotic inducer.