Centaurin Gamma 3 (CENTg3)

D7S1277i is located in the intron of the AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; also known as CRAG) gene, a GTPase activating protein for ADP ribosylation factors. AGAP3 is a novel GTPase that accelerates the degradation of abnormally elongated polyglutamine proteins through intranuclear inclusion body formation. AGAP3 is induced by reactive oxygen species and inhibits the progression of polyglutamine disease. Although the association between AGAP3 and glaucoma is unclear, AGAP3 polymorphisms may act as risk factors in the development of NTG.

D7S1277i may be associated with other gene(s) but not AGAP3 since MS markers are highly polymorphic and generally show wide linkage disequilibriums within 100–200 kb .