Centriolar Coiled Coil Protein Of 110kDa (CCP110)
CEP110; CP110; Centrosomal Protein Of 110 kDa
Centrosome duplication and separation are linked inextricably to certain cell cycle events, in particular activation of cyclin-dependent kinases (CDKs). However, relatively few CDK targets driving these events have been uncovered.CP110, which is phosphorylated by CDKs in vitro and in vivo. Human CP110 localizes to centrosomes. Its expression is strongly induced at the G1-to-S phase transition, coincident with the initiation of centrosome duplication. RNAi-mediated depletion of CP110 indicates that this protein plays an essential role in centrosome duplication. Long-term disruption of CP110 phosphorylation leads to unscheduled centrosome separation and overt polyploidy. CP110 is a physiological centrosomal CDK target that promotes centrosome duplication, and its deregulation may contribute to genomic instability.
Organism species: Homo sapiens (Human)
- Customized Service n/a Recombinant Centriolar Coiled Coil Protein Of 110kDa (CCP110) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) ELISA Kit Customized Service Offer
Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Centriolar Coiled Coil Protein Of 110kDa (CCP110) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Centriolar Coiled Coil Protein Of 110kDa (CCP110) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centriolar Coiled Coil Protein Of 110kDa (CCP110) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centriolar Coiled Coil Protein Of 110kDa (CCP110) ELISA Kit Customized Service Offer