Centromere Protein S (CENPS)

APITD1, within a 500-kb neuroblastoma tumor suppressor candidate region on chromosome 1p36.22. Transcript A encodes a deduced 138-amino acid protein with a calculated molecular mass of 16 kD, and transcript B encodes a deduced 99-amino acid protein with a calculated molecular mass of 11 kD. Both proteins contain a TAF9-like domain. Northern blot analysis of neuroblastoma cell lines detected ubiquitous expression of a major, approximately 1.5 kb and a minor, less than 1 kb transcript.

Expression of transcript A was generally higher in fetal tissues, whereas that of transcript B was higher in adult tissues. Expression of both was significantly reduced in several primary neuroblastoma tumors and in tumors of varied tissue origin.