Centrosomal Protein 152kDa (CEP152)

CEP152 is a core protein of the centrosome, a major microtubule-organizing center of animal cells that influences cell shape, polarity, and motility, and has a crucial function in cell division.

The transcript contains a repetitive element in its 3-prime end, and the deduced 1,209-amino acid protein shares significant similarity with Xenopus Numa protein (NUMA1). CEP152 in all tissues examined, with highest expression in brain, lung, kidney, pancreas, testis, and ovary, and lowest expression in spleen.The deduced protein contains 8 coiled-coil domains and has a calculated molecular mass of 151.5 kD. Fluorescence-tagged CEP152 associated with centrosomes in transfected U2OS cells, and salt extraction experiments revealed that it is a core centrosomal protein.