Centrosomal Protein 295kDa (CEP295)
KIAA1731/CEP295, specifically mediating centriole-to-centrosome conversion but dispensable for cartwheel removal. In the absence of CEP295, centrioles form in the S/G2 phase and lose their associated cartwheel in mitosis but cannot be converted to centrosomes, uncoupling the two events. Strikingly, centrioles devoid of both the PCM and the cartwheel progressively lose centriolar components, whereas centrioles associating with either the cartwheel or PCM alone can exist stably. Thus, cartwheel removal can have grave repercussions to centriole stability, and centriole-to-centrosome conversion mediated by CEP295 must occur in parallel to maintain cartwheel-less centrioles for duplication.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
- Customized Service n/a Recombinant Centrosomal Protein 295kDa (CEP295) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centrosomal Protein 295kDa (CEP295) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centrosomal Protein 295kDa (CEP295) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centrosomal Protein 295kDa (CEP295) CLIA Kit Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Centrosomal Protein 295kDa (CEP295) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centrosomal Protein 295kDa (CEP295) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centrosomal Protein 295kDa (CEP295) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centrosomal Protein 295kDa (CEP295) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centrosomal Protein 295kDa (CEP295) ELISA Kit Customized Service Offer