Centrosomal Protein 63kDa (CEP63)

CEP63 encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Not only have Professor Lane and his team published their findings about p53, but in the same week, Cancer Research UK’s Dr Vincenzo Costanzo has discovered an entirely new tumour suppressor, called Cep63.Cep63 seems to be able to block cells from dividing if anything seems amiss. And the protein appears to be involved in cancer – other scientists have recently discovered that Cep63 is faulty in invasive bladder cancers.