Centrosomal Protein 97kDa (CEP97)
LRRIQ2; Leucine-Rich Repeats And IQ Motif Containing 2
Mammalian centrioles play a dynamic role in centrosome function, but they also have the capacity to nucleate the assembly of cilia. Although controls must exist to specify these different fates, the key regulators remain largely undefined. CP110, a protein that plays an essential role in centrosome duplication and cytokinesis, and have identified a previously uncharacterized protein, Cep97, that recruits CP110 to centrosomes. Depletion of Cep97 or expression of dominant-negative mutants results in CP110 disappearance from centrosomes, spindle defects, and polyploidy. Remarkably, loss of Cep97 or CP110 promotes primary cilia formation in growing cells, and enforced expression of CP110 in quiescent cells suppresses their ability to assemble cilia, suggesting that Cep97 and CP110 collaborate to inhibit a ciliogenesis program.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Centrosomal Protein 97kDa (CEP97) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centrosomal Protein 97kDa (CEP97) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centrosomal Protein 97kDa (CEP97) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centrosomal Protein 97kDa (CEP97) ELISA Kit Customized Service Offer
Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Centrosomal Protein 97kDa (CEP97) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Centrosomal Protein 97kDa (CEP97) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Centrosomal Protein 97kDa (CEP97) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Centrosomal Protein 97kDa (CEP97) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Centrosomal Protein 97kDa (CEP97) ELISA Kit Customized Service Offer