Cerebellar Degeneration Related Protein 2 Like Protein (CDR2L)

Cdr2 is an autoimmune antigen targeted by “anti-Yo” antibodies associated with paraneoplastic cerebellar degeneration. CEN is a 790 amino acid protein that shares a highly conserved 110 amino acid domain near its amino-terminus that is similar to Cdr2L and Cdr2 and to orthologs found throughout metazoans. Cdr2 is reported to bind to the transcription factor Myc, sequestering it in the cytoplasm, through the association of the helix-leucine zipper motifs of Cdr2 and Myc. CEN, however, does not contain a predicted leucine zipper in the conserved domain, appearing more similar to Cdr2L in this regard, and therefore may not share the Myc-binding property of Cdr2. Other than Myc inhibition, the function of Cdr2 remains largely unknown, and no activity has been attributed to Cdr2L.