Cerebellin 4 (CBLN4)

Cerebellin is a sixteen aa peptide found mainly in the adrenal medulla, where it has been shown to have a neuromodulatory function. Cerebellin is derived from precerebellin, a protein with sequence similarity to the noncollagen domain of complement component C1qB.

Cerebellin 4 is a glycoprotein which shares sequence similarity with precerebellin. May be involved in synaptic functions in the CNS. Can enable ER export and secretion of CBLN3. Cerebellin is a 16-aminoacid peptide widely distributed in the central nervous system, where it exerts neuromodulatory functions. Cerebellin is contained in human adrenal medulla, and it has been recently demonstrated that cerebellin elicits catecholamine release by human adrenal in vitro.