Chaperonin Containing TCP1, Subunit 3 (CCT3)

CCT3 encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

The 1.9-kb cDNA encodes a predicted 544-amino acid protein that is 98% similar to the mouse sequence and 75% similar to the yeast gene. The mRNA is expressed in a variety of human tissues and at high levels in mouse testis.