Chaperonin Containing TCP1, Subunit 4 (CCT4)

The chaperonin containing TCP1 complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin and tubulin, as well as alpha-transducin.

The deduced 539-amino acid CCT4 protein shares homology with a number of chaperonin family proteins. Northern blot analysis detected a 2.0-kb CCT4 transcript in all tissues tested. Western blot analysis showed that CCT4 is expressed as a 62-kD protein.