Chaperonin Containing TCP1, Subunit 6A (CCT6A)

CCT6A encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

The amino acid sequence encoded by this cDNA clone, designated HTR3 by them (presumably for 'histidine transport regulator'), was related to that of the T-complex proteins.