Cholera Toxin (CT)
CTX; Choleragen
Cholera toxin is a protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A, enzymatic), and five copies of the B subunit (part B, receptor binding), denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The five B subunits—each weighing 12 kDa, form a five-membered ring. The A subunit has two important segments. The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) forms an extended alpha helix which sits snugly in the central pore of the B subunit ring. This structure is similar in shape, mechanism, and sequence to the heat-labile enterotoxin secreted by some strains of the Escherichia coli bacterium.
Organism species: Pan-species (General)
- Customized Service n/a Complete Antigen of Cholera Toxin (CT) Antigenic Transformation Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Cholera Toxin (CT) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Cholera Toxin (CT) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Cholera Toxin (CT) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Cholera Toxin (CT) ELISA Kit Customized Service Offer