Cholinergic Receptor, Nicotinic, Delta (CHRNd)

The delta gene was assigned by in situ hybridization to 2q31-q34. All pairs of RFLPs were analyzed for linkage disequilibrium. Of the 16 pairs of RFLPs from the same gene or from the linked gamma and delta genes, 13 showed evidence of significant disequilibrium (P less than 0.05). By Southern analysis of a panel of somatic cell hybrids and by in situ hybridization, Beeson et al. (1990) assigned the CHRND gene to 2q33-qter. Together with the earlier information, this suggests a location of 2q33-q34. Work of Pasteris et al. (1993) suggested a more distal location; a molecular analysis of a chromosome 2 deletion mapping panel suggested the following order: cen--PAX3--COL4A3--CHRND--tel. PAX3 is located in band 2q35 and COL4A3  is located in band 2q36.