Chromatin Modifying Protein 6 (CHMP6)

CHMP6 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A , is required for both MVB formation and regulation of cell cycle progression.

The deduced 201-amino acid protein contains 2 coiled-coil domains, an N-myristoylation site, and clusters of basic and acidic residues in its N- and C-terminal regions, respectively. Metabolic labeling confirmed that CHMP6 is myristoylated. Fluorescence-tagged CHMP6 localized in a punctate distribution in HeLa cells, mostly in the perinuclear area. .