Chromodomain Helicase DNA Binding Protein 7 (CHD7)

Using in situ hybridization, Sanlaville et al. (2006) analyzed the expression pattern of the CHD7 gene during early human development in normal human embryos and fetal tissues obtained after elective termination of pregnancy and found that CHD7 is widely expressed in undifferentiated neuroepithelium and in mesenchyme of neural crest origin. Towards the end of the first trimester it is expressed in dorsal root ganglia, cranial nerves and ganglia, and auditory, pituitary, and nasal tissues as well as in the neural retina.

Sanlaville et al. (2006) noted that there was good correlation between the CHD7 expression pattern and the developmental anomalies observed in CHARGE syndrome .