Chromosome 10 Open Reading Frame 76 (C10orf76)

C10orf76 contains a conserved proline-rich motif, suggesting that it may participate in protein-protein interactions via an SH3-binding domain, although no such interactions have been experimentally verified. The secondary structure is predicted to be completely helical in nature, with intervening regions of protein disorder. The potential SH3-binding domain is located on a predicted region of disorder, further supporting a protein-protein binding function for c10orf76. A helical region between amino acids 610-655 was predicted to be a coiled coil motif. A PHYRE2 protein structure prediction suggested that the first 200 residues of c10orf76 may share strong structural similarities with Symplekin, a nuclear-localized protein that is thought to be a scaffold component of the polyadenylation complex.