Laccase Domain Containing Protein 1 (LACC1)

C13ORF31 gene maps to chromosome 13q14.11. The SNPs in CCDC122 and C13ORF31 were associated with both multibacillary and paucibacillary forms of leprosy. However, the associations with the 2 SNPs in C13ORF31 were stronger for multibacillary than paucibacillary leprosy. The CCDC122 and C13ORF31 genes both map to chromosome 13q14.

Wong et al. (2010) proposed that association of the chromosome 13q14.11 locus containing C13ORF31 and CCDC122 with leprosy in these additional populations supports a molecular link between mycobacterial infection and Crohn disease , since the same chromosome 13q14.11 locus had been associated with Crohn disease in a genomewide association study by Barrett et al. (2008).