Chromosome 19 Open Reading Frame 25 (C19orf25)

Chromosome 19 Open Reading Frame 25 (C19orf25)
C19orf25, Belongs to the UPF0449 family. Mass spectrometric analysis of eluates of the tandem affinity purification of ZW10LAPtag and Zwint-1LAPtag from mitotically arrested cells showed that the two proteins resided in distinct kinetochore complexes. ZW10, however, resided in a complex with known interacting partners Rod and Zwilch. In addition, Rad50-interactor-1, a protein proposed to bind ZW10 in interphase, was present. So too was a novel, previously hypothetical protein FLJ36666/C19ORF25. Neither Rad50-interactor-1 nor C19ORF25 bound kinetochores when fused to EYFP (unpublished data), however, supporting the likelihood that they are part of an interphase ZW10-containing protein structure.

Organism species: Homo sapiens (Human)

Organism species: Mus musculus (Mouse)

Organism species: Rattus norvegicus (Rat)