New Component Of The BRCA1 A Complex 1 (NBA1)

MERIT40 was part of a BRCA1-associated protein complex containing BRE, BRCC36 (BRCC3), CCDC98 , and RAP80 (UIMC1).The MERIT40-BRE interaction also stabilized the entire protein complex, which was required for efficient BRCA1 foci formation and function at sites of DNA damage.

NBA1 was part of a BRCA1-associated complex in human cell lines and was required for BRCA1 focus formation. Knockdown of NBA1 via short hairpin RNA led to increased sensitivity of cells to DNA damage caused by IR, ultraviolet radiation, and chemical DNA-damaging agents. NBA1-depleted human osteosarcoma cells were unable to arrest efficiently in G2 in response to IR.