Chromosome X Open Reading Frame 66 (CXorf66)

CXorf66 protein has a predicted signal peptide from 1-19aa, a topological domain from 20-47aa, a transmembrane domain from 48-68aa, and a second topological domain from 69-361aa. A signal peptide cleavage site is predicted to occur between the 17-18aa. CXorf66 has a moderately high expression levels in testes, in addition to higher expression levels in fetus tissue in comparison to other developmental stages. CXorf66 protein also has a notable low presence in both the control endometrium total RNA and endometriosis total RNA CXorf66 has been portrayed to have notable presence in the plasma and platelet Based upon PaxDb data, CXorf66 has been found ranking in the top 5% for one study of human plasma and in the top 25% for another study conducted with human platelet.