Cingulin Like Protein 1 (CGNL1)

By sequencing clones obtained from a size-fractionated fetal brain cDNA library, Nagase et al. (2000) cloned a partial CGNL1 cDNA, which they designated KIAA1749. RT-PCR followed by ELISA detected high expression in smooth muscle, spleen, testis, fetal brain, and the amygdala, corpus callosum, cerebellum, thalamus, and subthalamic nucleus of adult brain.the regulatory regions upstream of the CGNL1 and TMOD3 promoters are similar.

The mouse homolog of CGNL1 has been designated JACOP (junction-associated coiled-coil protein). JACOP is recruited to the junctional complex in epithelial cells and to cell-cell contacts in fibroblasts. It has been suggested that JACOP is involved in anchoring cell-cell contacts to actin-based cytoskeletons within cells.