Claudin 25 (CLDN25)

CLDN25 Belongs to the claudin family.The claudin (CLDN) genes encode a family of proteins important in tight junction formation and function. Recently, it has become apparent that CLDN gene expression is frequently altered in several human cancers. However, the exact patterns of CLDN expression in various cancers is unknown, as only a limited number of CLDN genes have been investigated in a few tumors.The claudin family consists of approximately 23 proteins that are essential for the formation of tight junctions (TJs) in epithelial and endothelial cells. TJs have crucial roles in the control of paracellular transport and in the maintenance of cell polarity. It is thought that various claudin family members can confer different properties to epithelial cell permeability and account for some of the selective variability of different barriers.