Cleavage And Polyadenylation Specific Factor 6 (CPSF6)

CPSF6 is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitement of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins.The deduced 551-amino acid 68-kD subunit contains 3 distinct domains: an N-terminal RNA-binding domain of the ribonucleoprotein (RNP) type, a proline-rich middle section, and a C-terminal alternating charge domain, which is composed almost exclusively of arginine residues alternating with glutamate and aspartate residues and several serine/arginine dipeptides.