Cleavage Stimulation Factor 3 (CSTF3)

CSTF3 is one of three (including CSTF1 and CSTF2) cleavage stimulation factors that combine to form the cleavage stimulation factor complex (CSTF). This complex is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. The encoded protein functions as a homodimer and interacts directly with both CSTF1 and CSTF2 in the CSTF complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Northern blot analysis of several human tissues detected a 3.2-kb transcript predominantly in lung. In mouse, Cstf3 expression was strong during embryonic development beginning at embryonic day 11 and much weaker in adult tissues.