Coatomer Protein Complex Subunit Gamma 2 (COPg2)

COPG2, a novel imprinted gene that overlaps with MEST and is transcribed from the paternally inherited allele in most fetal tissues, providing clear evidence that imprinting in 7q32 is regional. Expression was biallelic in fetal brain and liver and in adult peripheral blood. Biallelic expression in blood was supported by the demonstration of COPG2 transcripts in lymphoblastoid cell lines with maternal uniparental disomy 7.biallelic expression of COPG2 in all fetal tissues examined and in adult blood lymphocytes. On the other hand, CIT1 (COPG2IT1), an antisense transcript of COPG2 intron 20, was expressed from the paternal allele in all fetal tissues examined. Adult blood lymphocytes showed biallelic expression of CIT1.The binding of CDC42 to COPG2 is essential for a transforming signal distinct from those elicited by Ras.