Coenzyme Q9 Homolog (COQ9)

Coenzyme Q10 (CoQ10), or ubiquinone, is a mobile lipophilic electron carrier critical for electron transfer by the mitochondrial inner membrane respiratory chain. COQ9 is 1 of several enzymes involved in biosynthesis of CoQ10 and likely functions in modification of the benzoquinone ring (Duncan et al., 2009).Using RT-PCR, Duncan et al. (2009) cloned COQ9 from normal human fibroblast RNA. The deduced 318-amino acid protein is highly conserved in several mammalian species and in chicken and zebrafish.Johnson et al. (2005) reported that Coq9 was required for biosynthesis of coenzyme Q in S. cerevisiae.By genomic sequence analysis, Loftus et al. (1999) mapped the COQ9 gene to chromosome 16. Duncan et al. (2009) stated that the COQ9 gene maps to chromosome 16q13.