Coiled Coil Domain Containing Protein 25 (CCDC25)

CCDC25 The protein is highly conserved among mammals as well as eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a single polypeptide chain 208 amino acids in length and is expressed at a high level, nearly 4.2 times that of a normal human protein. Its expression is nearly ubiquitous in human tissues with little indication that its expression level changes drastically in diseased tissues. Despite currently lacking a well understood function, CCDC25 is predicted to localize to the nucleus and was shown by a microarray experiment to be upregulated in Metaphase II oocytes. CCDC25 was shown by a yeast-two-hybrid assay to interact with Smad2, a latent transcription factor that is part of the TGF-β signaling pathway.