Coiled Coil Helix Coiled Coil Helix Domain Containing Protein 8 (CHCHD8)

To identify genes that are regulated by or associated with estrogen action, Charpentier et al. (2000) performed serial analysis of gene expression (SAGE) on estrogen-responsive breast cancer cells after exposure to estrogen. Using transcript-specific PCR primers for novel sequences that increased more than 10-fold upon treatment with 17-beta estradiol (E2), they cloned 5 cDNAs, designated E2-induced genes (E2IG) 1-5, from a human placenta cDNA library.

The E2IG2 cDNA encodes a deduced 97-amino acid protein. The International Radiation Hybrid Mapping Consortium mapped the E2IG2 gene to chromosome 11.