Collagen Type VI Alpha 4 (COL6a4)
DVWA; DIVA; COL6A4P1; vWA6; Dual von Willebrand Factor A Domains; Von Willebrand Factor A Domain Containing Protein 6
While performing a genomewide association study of osteoarthritis susceptibility, Miyamoto et al. (2008) isolated the DVWA gene by RACE and RT-PCR analysis of LOC344875. The 2,250-basepair DVWA gene encodes a protein of 276 amino acids that lacks a signal peptide and contains 2 domains homologous to the von Willebrand factor A (VWA) domain.
Highest expression of DVWA was seen in normal and osteoarthritic cartilage using real-time PCR. Immunoprecipitation analysis of transfected cells followed by MALDI-TOF mass spectrometry analysis revealed that DVWA binds to beta-tubulin (TUBB); binding was confirmed by immunoprecipitation and protein blot analyses.For discussion of a possible association between variation in the DWVA gene and susceptibiity to osteoarthritis.
Organism species: Mus musculus (Mouse)
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