Collagen Type VI Alpha 6 (COL6a6)
The three new genes are COL6A4, COL6A5 and that encode the α4(VI), α5(VI) and α6(VI) chains. In humans, the COL6A4 gene has been disrupted by a chromosome break. Each of the three new collagen chains contain a 336 amino acid triple helix flanked by seven N-terminal von Willebrand factor A-like-domains (VWA-domains) and two (α4 and α6 chains) or three (α5 chain) C-terminal VWA-domains. In humans, mRNA expression of COL6A5 is restricted to a few tissues including lung, testis and colon. In contrast, the COL6A6 gene is expressed in a wide range of fetal and adult tissues including lung, kidney, liver, spleen, thymus, heart and skeletal muscle. Antibodies to the α6(VI) chain stained the extracellular matrix of human skeletal and cardiac muscle, lung and the territorial matrix of articular cartilage.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
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