Collectin Kidney 1 (CLK1)

COLEC11 is a member of the collectin family of C-type lectins, which contain a collagen-like domain and a carbohydrate recognition domain, and play a role in host-defense (Keshi et al., 2006).COLEC11 binds a variety of microbial saccharides including LPS from E. coli and Klebsiella pneumoniae, as well as S. cerevisiae mannan.

By EST database screening using the carbohydrate recognition domain (CRD) of human liver collectin, CLL1 (COLEC10), followed by 5-prime RACE of human kidney cDNA libraries, Keshi et al. (2006) cloned COLEC11, which they called CLK1. The deduced 271-amino acid COLEC11 protein contains an N-terminal region with a cysteine residue, a collagen-like sequence, a neck region, a CRD, and a predicted signal peptide of 25-amino acids; the mature predicted protein consists of 246 amino acids.