Cord Factor (CF)

Cord factor is a glycolipid molecule found in the cell wall of Mycobacterium tuberculosis and similar species. It is the primary lipid found on the exterior of M. tuberculosis cells. Cord factor influences the arrangement of M. tuberculosis cells into long and slender formations, giving its name. Cord factor is virulent towards mammalian cells and critical for survival of M. tuberculosis in hosts, but not outside of hosts. Cord factor has been observed to influence immune responses, induce the formation of granulomas, and inhibit tumor growth. A cord factor molecule is composed of a trehalose sugar, a disaccharide, that is esterified to two mycolic acid residues. One of the two mycolic acid residues is attached to the sixth carbon of one mo nosaccharide, while the other mycolic acid residue is attached to the sixth carbon of the other monosaccharide. Therefore, cord factor is also named trehalose-6,6'-dimycolate.