Cornichon Homolog (CNIH)

CNIH encodes a deduced 134-amino acid protein with 63% homology to the fly protein. Northern blot analysis detected a 1.4-kb CNIH transcript at high levels in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid, testis, spleen, appendix, peripheral blood lymphocytes, and bone marrow, and at low levels in brain, placenta, lung, kidney, ovary, small intestine, stomach, lymph node, thymus, and fetal liver.

The first predicted loop between TMD1 and TMD2 has 3 conserved acid residues and is predicted to face the lumen of the endoplasmic reticulum. The segment between TMD2 and TMD3 is predicted to face the cytosol.human CNIH complemented the loss of Erv14p in yeast.