Cortexin 1 (CTXN1)

Cortexin is an 82-amino acid protein that is highly enriched in precursor neurons of the cortical plate of fetal rodent brain and in pyramidal neurons of adult rodent cerebral cortex and hippocampus (Watson et al., 1992; Coulter et al., 1993). Because of a putative single membrane-spanning domain in the middle of the cortexin amino acid sequence, cortexin is likely to be an integral membrane protein that may mediate extracellular or intracellular signaling of cortical neurons during forebrain development (Watson et al., 1994).

By linkage analysis of RFLVs in interspecific backcrosses, the Ctxn gene was mapped to mouse chromosome 8 (Watson et al., 1994).