Crk Like Protein (CRKL)
V-Crk Sarcoma Virus CT10 Oncogene Homolog(avian)-Like
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL.
In addition, CRKL has oncogenic potential.CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.CRKL becomes phosphorylated when overexpressed, activates Ras-dependent and JNK pathways, and transforms fibroblasts. The authors also found CRKL to be a substrate for the BCR-ABL tyrosine kinase (ABL), leading them to conclude that CRKL is a tyrosine kinase and an oncogene.
Organism species: Homo sapiens (Human)
- Recombinant protein RPG766Hu01 Recombinant Crk Like Protein (CRKL) In Stock
- Monoclonal antibody MAG766Hu21 Monoclonal Antibody to Crk Like Protein (CRKL) In Stock
- Polyclonal antibody PAG766Hu01 Polyclonal Antibody to Crk Like Protein (CRKL) In Stock
- Sandwich ELISA SEG766Hu ELISA Kit for Crk Like Protein (CRKL) In Stock
Organism species: Mus musculus (Mouse)
- Recombinant protein RPG766Mu01 Recombinant Crk Like Protein (CRKL) In Stock
- Recombinant protein RPG766Mu02 Recombinant Crk Like Protein (CRKL) In Stock
- Polyclonal antibody PAG766Mu01 Polyclonal Antibody to Crk Like Protein (CRKL) In Stock
- Polyclonal antibody PAG766Mu02 Polyclonal Antibody to Crk Like Protein (CRKL) In Stock
- Sandwich ELISA SEG766Mu ELISA Kit for Crk Like Protein (CRKL) In Stock
Organism species: Rattus norvegicus (Rat)
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- Customized Service n/a Monoclonal Antibody to Crk Like Protein (CRKL) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Crk Like Protein (CRKL) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Crk Like Protein (CRKL) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Crk Like Protein (CRKL) ELISA Kit Customized Service Offer