Crumbs Homolog 1 (CRB1)

LCA8; RP12
Crumbs Homolog 1 (CRB1)
Crumbs homolog 1 is a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye.
Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternatively spliced transcript variants have been observed but their full-length nature has yet to be determined. One small study suggests that mutations in this gene are associated with keratoconus in patients that already have Leber's congenital amaurosis.
Organism species: Homo sapiens (Human)
  • Protein RPF775Hu01Recombinant Crumbs Homolog 1 (CRB1)Customize
  • AntibodyPAF775Hu01Polyclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • AntibodyMAF775Hu21Monoclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSEF775HuELISA Kit for Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSCF775HuCLIA Kit for Crumbs Homolog 1 (CRB1)Customize
Organism species: Mus musculus (Mouse)
  • Protein RPF775Mu01Recombinant Crumbs Homolog 1 (CRB1)Customize
  • AntibodyPAF775Mu01Polyclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • AntibodyMAF775Mu21Monoclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSEF775MuELISA Kit for Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSCF775MuCLIA Kit for Crumbs Homolog 1 (CRB1)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPF775Ra01Recombinant Crumbs Homolog 1 (CRB1)Customize
  • AntibodyPAF775Ra01Polyclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • AntibodyMAF775Ra21Monoclonal Antibody to Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSEF775RaELISA Kit for Crumbs Homolog 1 (CRB1)Customize
  • Assay KitSCF775RaCLIA Kit for Crumbs Homolog 1 (CRB1)Customize
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