Crystallin Gamma C (CRYgC)

Interactions between mutated crystallins alpha-A (R116C), alpha-B (R120G), and gamma-C (T5P) and the corresponding wildtype proteins, as well as with wildtype beta-B2-crystallin and HSP27, were analyzed in a mammalian cell 2-hybrid system. For mutated alpha-A-crystallin, interactions with wildtype beta-B2-crystallin and gamma-C-crystallin decreased and those with wildtype alpha-B-crystallin and HSP27 increased.

For mutated alpha-B-crystallin, the interactions with wildtype alpha-A-crystallin and alpha-B-crystallin decreased, but those with wildtype beta-B2-crystallin and gamma-C-crystallin increased slightly. For mutated gamma-C-crystallin, most of the interactions were decreased.