Cullin 7 (CUL7)

Nomura et al. (1994) cloned CUL7, which they designated KIAA0076. The deduced 1,698-amino acid protein contains an ATP/GTP-binding site motif A and motifs found in mitochondrial energy transfer proteins. Northern blot analysis detected CUL7 expression in all tissues and cell lines tested except testis and small intestine.

By immunoprecipitating proteins that interacted with epitope-tagged ROC1 (RBX1) in human embryonic kidney cells, Dias et al. (2002) identified CUL7. The N-terminal half of CUL7 contains a 72-amino acid domain enriched in glycine and acidic residues that is similar to a corresponding region in HERC2. CUL7 also has a central DOC domain and a C-terminal cullin domain.