Cyclin B1 Interacting Protein 1 (CCNB1IP1)
HEI10; C14orf18; Human Enhancer Of Invasion 10; E3 ubiquitin-protein ligase CCNB1IP1
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M. HEI10 expression in Xenopus oocytes showed that HEI10 acts as an E3 ubiquitin ligase, causing delayed entry into mitosis by reducing cyclin B levels. In vitro, the cyclin B-cdc2 complex phosphorylated HEI10 primarily at the NTPVR cell cycle kinase consensus site.
The protein contains a divergent RING finger motif in the N terminus, a coiled-coil domain, and cyclin and cyclin-dependent kinase phosphorylation sites in the C terminus. Northern blot analysis identified a 1.6-kb HEI10 transcript that was expressed at high levels in heart, moderate levels in kidney and liver, and low levels in placenta, brain, and lung.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Cyclin B1 Interacting Protein 1 (CCNB1IP1) Recombinant Protein Customized Service Offer
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- Customized Service n/a Polyclonal Antibody to Cyclin B1 Interacting Protein 1 (CCNB1IP1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Cyclin B1 Interacting Protein 1 (CCNB1IP1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Cyclin B1 Interacting Protein 1 (CCNB1IP1) ELISA Kit Customized Service Offer