Cyclin Dependent Kinases Regulatory Subunit 1 (CKS1)

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. CKS1 is required for both the periodic dissociation of CDC28 kinase from the CDC20 promoter and the periodic association of the proteasome with the promoter. CKS1 is to recruit the proteasome to, and/or dissociate the CDC28 kinase from, the CDC20 promoter, thus facilitating transcription by remodeling transcriptional complexes or chromatin associated with the CDC20 gene.