Cyclin E (CCNE)
CCNE1; CCN-E; Cyclin Es; Cyclin Et; G1/S-specific cyclin-E1
Cyclin E belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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- Customized Service n/a Monoclonal Antibody to Cyclin E (CCNE) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Cyclin E (CCNE) Polyclonal Antibody Customized Service Offer
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Cyclin E (CCNE) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Cyclin E (CCNE) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Cyclin E (CCNE) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Cyclin E (CCNE) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Cyclin E (CCNE) ELISA Kit Customized Service Offer