Cyclin L1 (CCNL1)
CCN-L1; BM-001; Ania-6a
Cyclin L, a novel cyclin related to the C-type cyclins that are involved in regulation of RNA polymerase II (pol II) transcription. Cyclin L also contains a COOH-terminal dipeptide repeat of alternating arginines and serines, a hallmark of the SR family of splicing factors. cyclin L interacts with p110 PITSLRE kinase, and that cyclin L antibody co-immunoprecipitates a kinase activity from HeLa nuclear extracts that phosphorylates the carboxyl-terminal domain (CTD) of pol II and splicing factor SC35, and is inhibited by the cdk inhibitor p21. Cyclin L antibody inhibits the second step of RNA splicing in vitro, and recombinant cyclin L protein stimulates splicing under suboptimal conditions.Cyclin L and its associated kinase are thus new members of the pre-mRNA processing machinery.
Organism species: Homo sapiens (Human)
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Organism species: Mus musculus (Mouse)
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Organism species: Rattus norvegicus (Rat)
- Customized Service n/a Recombinant Cyclin L1 (CCNL1) Recombinant Protein Customized Service Offer
- Customized Service n/a Monoclonal Antibody to Cyclin L1 (CCNL1) Monoclonal Antibody Customized Service Offer
- Customized Service n/a Polyclonal Antibody to Cyclin L1 (CCNL1) Polyclonal Antibody Customized Service Offer
- Customized Service n/a CLIA Kit for Cyclin L1 (CCNL1) CLIA Kit Customized Service Offer
- Customized Service n/a ELISA Kit for Cyclin L1 (CCNL1) ELISA Kit Customized Service Offer