Cyclin M2 (CNNM2)

Mouse Acdp2, which encodes a deduced 874-amino acid protein that shares 97% identity with human ACDP2. Acdp2 contains 4 transmembrane domains, 2 CBS domains, a DUF21 domain, and a cNMP-binding domain. It also has a glycine-rich region. Acdp2 contains 4 transmembrane regions and possible sites for N-glycosylation and phosphorylation. RT-PCR detected highest Acdp2 expression in kidney and brain, with lower amounts in all other tissues examined.In addition, all 4 contain a 31-amino acid sequence motif that is present in the cyclin box, a cyclic nucleotide-monophosphate (cNMP)-binding domain, and 2 CBS domains. The ACDP2 gene, designated CNNM2 by the HUGO Nomenclature Committee, encodes a deduced 875-amino acid protein.