Cysteine And Histidine Rich Domain Containing Protein 1 (CHORDC1)

Shirasu et al. (1999) cloned the cDNA of a human gene, designated CHP1, that encodes a 332-amino acid protein containing 2 CHORD domains. CHORD was defined as a 60-amino acid, cysteine- and histidine-rich, Zn(2+)-binding domain that is conserved in tandem organization in protozoa, plants, and metazoa.

Shirasu et al. (1999) found that silencing of the C. elegans CHORD-containing gene, chp, resulted in semisterility and embryo lethality, suggesting an essential function of the wildtype gene in nematode development.

CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1. Interacts with HSP90AA1 and HSP90AB1 in an ATP-independent manner. Interacts with PPP5C