Cysteine Serine Rich Nuclear Protein 1 (CSRNP1)

CSRNP1 encodes a protein that localizes to the nucleus and expression of this gene is induced in response to elevated levels of axin. The Wnt signalling pathway, which is negatively regulated by axin, is important in axis formation in early development and impaired regulation of this signalling pathway is often involved in tumors.

Transfection experiments localized AXUD1 mainly to the nuclei. Northern blot analysis detected expression of a 3.2-kb AXUD1 transcript in all human tissues examined, with highest expression in lung, placenta, skeletal muscle, pancreas, and leukocyte. AXUD1 was frequently downregulated in lung, kidney, liver and colon cancers compared with the corresponding normal tissues, suggesting that AXUD1 may have a tumor suppressor function in these organs.