Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

ABC35; ABCC7; CF; CFTR/MRP; MRP7; TNR-CFTR; ATP-Binding Cassette Subfamily C,Member 7; Channel conductance-controlling ATPase; cAMP-dependent chloride channel
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)
Cystic fibrosis transmembrane conductance regulator (CFTR) is an ABC transporter-class protein and ion channel that transports chloride ions across epithelial cell membranes. Mutations of the CFTR gene affect functioning of the chloride ion channels in these cell membranes, leading to cystic fibrosis and congenital absence of the vas deferens.
The gene that encodes for CFTR is found on the human chromosome 7, on the long arm at position q31.2. It contains about 170,000 base pairs. The encoded CFTR is a glycoprotein with 1480 amino acids. The protein consists of five domains. There are two transmembrane domains, each with six spans of alpha helices. These are each connected to a nucleotide binding domain (NBD) in the cytoplasm.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
  • Protein RPC425Mu01Recombinant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • AntibodyPAC425Mu01Polyclonal Antibody to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • AntibodyMAC425Mu21Monoclonal Antibody to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • Assay KitSEC425MuELISA Kit for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • Assay KitSCC425MuCLIA Kit for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
Organism species: Rattus norvegicus (Rat)
  • Protein RPC425Ra01Recombinant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • AntibodyPAC425Ra01Polyclonal Antibody to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • AntibodyMAC425Ra21Monoclonal Antibody to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • Assay KitSEC425RaELISA Kit for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
  • Assay KitSCC425RaCLIA Kit for Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)Customize
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